Close to 100 Ameri­cans are killed by opioids each day, a figure that could rise to 250 — or more than 650,000 over the next decade — if potent synthetic compounds such as fentanyl and carfen­tanil continue to prolif­erate while waiting time for treat­ment lengthens in the hardest-hit areas, according to this analysis. Experts predict that mortality will not stabi­lize until after 2020, because it will take several years to see if govern­ment inter­ven­tions are effective.